| Primary Identifier | MGI:96552 | Organism | mouse, laboratory |
| Chromosome | 11 | NCBI Gene Number | 16187 |
| Mgi Type | protein coding gene |
| description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0) Enables cytokine activity; growth factor activity; and interleukin-3 receptor binding activity. Acts upstream of or within several processes, including negative regulation of leukocyte apoptotic process; positive regulation of leukocyte proliferation; and regulation of phosphate metabolic process. Located in extracellular space. Is expressed in several structures, including hemolymphoid system; liver; reproductive system; vascular system; and yolk sac. Human ortholog(s) of this gene implicated in Graves ophthalmopathy; Graves' disease; asthma; and rheumatoid arthritis. Orthologous to human IL3 (interleukin 3). PHENOTYPE: Mice homozygous for disruptions in this gene show abnormal mast cell development. Contact hypersensitivity is reduced and resistance to parasitic invections is increased. [provided by MGI curators] |
Features --> Cross References
Canonical gene --> CDSs in specific strains.
Canonical gene --> Exons in specific strains
Canonical gene --> Strain-specific IDs, biotypes, and locations
Canonical gene --> Transcripts in specific strains.
Features --> Overlapping features
