| Primary Identifier | MGI:2444668 | Organism | mouse, laboratory |
| Chromosome | 11 | NCBI Gene Number | 216742 |
| Mgi Type | protein coding gene |
| description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0) Predicted to enable several functions, including ATPase inhibitor activity; enzyme activator activity; and protein-folding chaperone binding activity. Acts upstream of or within with a positive effect on negative regulation of cell population proliferation. Acts upstream of or within several processes, including negative regulation of TOR signaling; negative regulation of cysteine-type endopeptidase activity; and positive regulation of B cell apoptotic process. Located in cytoplasm. Human ortholog(s) of this gene implicated in primary immunodeficiency disease. Orthologous to human FNIP1 (folliculin interacting protein 1). PHENOTYPE: Mice homozygous for an ENU-induced or targeted allele exhibit arrested B cell development at the pre-B cell stage with increased B cell apoptosis. [provided by MGI curators] |
Features --> Cross References
Canonical gene --> CDSs in specific strains.
Canonical gene --> Exons in specific strains
Canonical gene --> Strain-specific IDs, biotypes, and locations
Canonical gene --> Transcripts in specific strains.
Features --> Overlapping features
