| Primary Identifier | MGI:1197527 | Organism | mouse, laboratory |
| Chromosome | 11 | NCBI Gene Number | 21975 |
| Mgi Type | protein coding gene |
| description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0) Predicted to enable DNA topoisomerase type I (single strand cut, ATP-independent) activity and single-stranded DNA binding activity. Predicted to be involved in DNA metabolic process and chromosome separation. Predicted to be located in PML body. Predicted to be part of RecQ family helicase-topoisomerase III complex. Predicted to be active in nucleus. Is expressed in several structures, including cardiovascular system; central nervous system; genitourinary system; gut; and sensory organ. Human ortholog(s) of this gene implicated in autosomal recessive progressive external ophthalmoplegia with mitochondrial DNA deletions 5. Orthologous to human TOP3A (DNA topoisomerase III alpha). PHENOTYPE: Mice homozygous for a null allele die shortly after implantation and the induction of decidual reaction. [provided by MGI curators] |
Features --> Cross References
Canonical gene --> CDSs in specific strains.
Canonical gene --> Exons in specific strains
Canonical gene --> Strain-specific IDs, biotypes, and locations
Canonical gene --> Transcripts in specific strains.
Features --> Overlapping features
