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Protein Coding Gene : Shmt1 serine hydroxymethyltransferase 1 (soluble)
Primary Identifier  MGI:98299 Organism  mouse, laboratory
Chromosome  11 NCBI Gene Number  20425
Mgi Type  protein coding gene
description  FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0)

Enables glycine hydroxymethyltransferase activity. Involved in dTMP biosynthetic process and tetrahydrofolate interconversion. Acts upstream of or within cellular response to leukemia inhibitory factor. Located in mitochondrion. Is active in nucleus. Is expressed in several structures, including alimentary system; brain ventricular layer; genitourinary system; liver and biliary system; and skin. Human ortholog(s) of this gene implicated in breast cancer. Orthologous to human SHMT1 (serine hydroxymethyltransferase 1).
PHENOTYPE: Mice with deficiencies in this gene display abnormalities in hepatic partioning of methylenetetrahydrofolate but are otherwise healthy and fertile. [provided by MGI curators]
  • synonyms:
  • Shmt1,
  • MGI:2144665,
  • AI324848,
  • C81125,
  • AI385541,
  • expressed sequence AI385541,
  • Shmt,
  • mshmt1,
  • expressed sequence AI324848,
  • MGI:2144126,
  • serine hydroxymethyl transferase (soluble),
  • mshmt,
  • expressed sequence C81125,
  • mshmt2,
  • serine hydroxymethyltransferase 1 (soluble),
  • MGI:2144138,
  • MGD-MRK-14406,
  • serine hydroxymethyl transferase
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