Primary Identifier | MGI:2384931 | Organism | mouse, laboratory |
Chromosome | 11 | NCBI Gene Number | 216820 |
Mgi Type | protein coding gene |
description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0) Enables DNA-binding transcription factor binding activity and transcription corepressor activity. Involved in ether lipid biosynthetic process and neutrophil differentiation. Acts upstream of or within several processes, including brown fat cell differentiation; phosphatidylcholine biosynthetic process; and regulation of cold-induced thermogenesis. Located in membrane; nucleus; and peroxisome. Part of transcription regulator complex. Orthologous to human DHRS7B (dehydrogenase/reductase 7B). PHENOTYPE: Mice homozygous for a gene trap mutation die by weaning age and exhibit esophageal and gastric lesions. Thymic atrophy and muscle degeneration is also seen. [provided by MGI curators] |