Primary Identifier | MGI:1916997 | Organism | mouse, laboratory |
Chromosome | 11 | NCBI Gene Number | 69747 |
Mgi Type | protein coding gene |
description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0) Predicted to enable zinc ion binding activity. Predicted to be involved in double-strand break repair via homologous recombination and protein stabilization. Predicted to be located in nucleus. Predicted to be part of Shu complex. Human ortholog(s) of this gene implicated in 46 XX gonadal dysgenesis and spermatogenic failure 71. Orthologous to human ZSWIM7 (zinc finger SWIM-type containing 7). PHENOTYPE: Mice homozygous for a knock-out allele exhibit female and male infertility with decreased testis and ovary weights, azoospermia, absent ovarian follicles and impaired chromosomal synapsis. [provided by MGI curators] |