| Primary Identifier | MGI:1349717 | Organism | mouse, laboratory |
| Chromosome | 11 | NCBI Gene Number | 20185 |
| Mgi Type | protein coding gene |
| description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0) Enables several functions, including histone deacetylase regulator activity; nuclear receptor binding activity; and transcription corepressor activity. Involved in several processes, including establishment of skin barrier; locomotor rhythm; and protein stabilization. Acts upstream of or within several processes, including hemopoiesis; regulation of gene expression; and regulation of intracellular signal transduction. Located in cytoplasm and nucleus. Part of transcription repressor complex. Is expressed in several structures, including alimentary system; central nervous system; genitourinary system; integumental system; and sensory organ. Orthologous to human NCOR1 (nuclear receptor corepressor 1). PHENOTYPE: Mice homozygous for a targeted mutation in this gene exhibit embryonic lethality with erythrocytic, thymocytic and central nervous system development abnormalities. Mice homozygous for a hypomorphic allele exhibit increased thyroid hormone sensitivity under hypothyroid conditions. [provided by MGI curators] |
Features --> Cross References
Canonical gene --> CDSs in specific strains.
Canonical gene --> Exons in specific strains
Canonical gene --> Strain-specific IDs, biotypes, and locations
Canonical gene --> Transcripts in specific strains.
Features --> Overlapping features
