Primary Identifier | MGI:1341836 | Organism | mouse, laboratory |
Chromosome | 11 | NCBI Gene Number | 22368 |
Mgi Type | protein coding gene |
description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0) Enables calcium channel activity. Involved in positive regulation of axon extension; positive regulation of calcium ion import; and positive regulation of cold-induced thermogenesis. Located in cell body; cell surface; and growth cone. Is expressed in central nervous system; dorsal root ganglion; sensory organ; and testis. Orthologous to human TRPV2 (transient receptor potential cation channel subfamily V member 2). PHENOTYPE: Mice homozygous for a knock-out allele exhibit impaired macrophage migration, binding, and phagocytosis with increased susceptiblity and mortality following bacterial infection. [provided by MGI curators] |