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Protein Coding Gene : Gas7 growth arrest specific 7
Primary Identifier  MGI:1202388 Organism  mouse, laboratory
Chromosome  11 NCBI Gene Number  14457
Mgi Type  protein coding gene
description  FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0)

Enables actin filament binding activity. Acts upstream of or within actin filament organization; neuron projection morphogenesis; and regulation of cell shape. Located in actin filament and ruffle. Is expressed in forebrain. Orthologous to human GAS7 (growth arrest specific 7).
PHENOTYPE: Aged mice homozygous for a hypomorphic allele show impaired coordination, decreased grip strength, decreased motor neuron number, muscle weakness, abnormal skeletal muscle fiber type ratio in the soleus muscle, and defects in motor neuron axon terminal sprouting. [provided by MGI curators]
  • synonyms:
  • AW124766,
  • Gas7,
  • RIKEN cDNA B230343A10 gene,
  • expressed sequence AW124766,
  • B230343A10Rik,
  • MGI:2443165,
  • Gas7-cb,
  • growth arrest specific 7,
  • MGI:2144503
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