| Primary Identifier | MGI:105088 | Organism | mouse, laboratory |
| Chromosome | 11 | NCBI Gene Number | 18208 |
| Mgi Type | protein coding gene |
| description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0) Predicted to be an extracellular matrix structural constituent. Involved in chemorepulsion of axon and regulation of synapse assembly. Acts upstream of or within several processes, including generation of neurons; inner ear morphogenesis; and regulation of neurogenesis. Located in basement membrane and cytoplasm. Is active in glutamatergic synapse. Is expressed in several structures, including alimentary system; central nervous system; integumental system; lung; and sensory organ. Human ortholog(s) of this gene implicated in congenital mirror movement disorder. Orthologous to human NTN1 (netrin 1). PHENOTYPE: Homozygotes for targeted mutations exhibit impaired axonal migration, abnormal semicircular canals, lack of corpus callosum, aberrant commissures, optic nerve hypoplasia, motor and balance defects, failure to suckle, and neonatal death. Embryos homozygous for a null allele show bilateral coloboma and cleft secondary palate. [provided by MGI curators] |
Features --> Cross References
Canonical gene --> CDSs in specific strains.
Canonical gene --> Exons in specific strains
Canonical gene --> Strain-specific IDs, biotypes, and locations
Canonical gene --> Transcripts in specific strains.
Features --> Overlapping features
