| Primary Identifier | MGI:2443588 | Organism | mouse, laboratory |
| Chromosome | 11 | NCBI Gene Number | 320207 |
| Mgi Type | protein coding gene |
| description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0) Predicted to enable 1-phosphatidylinositol-3-kinase regulator activity and G-protein beta/gamma-subunit complex binding activity. Predicted to be involved in several processes, including phosphatidylinositol 3-kinase/protein kinase B signal transduction; phosphatidylinositol metabolic process; and positive regulation of intracellular signal transduction. Predicted to be located in centriolar satellite; cytosol; and membrane. Predicted to be part of phosphatidylinositol 3-kinase complex, class IA and phosphatidylinositol 3-kinase complex, class IB. Is expressed in brain and retina nuclear layer. Human ortholog(s) of this gene implicated in ataxia with oculomotor apraxia type 3 and colon cancer. Orthologous to human PIK3R5 (phosphoinositide-3-kinase regulatory subunit 5). PHENOTYPE: Mice homozygous for a knock-out allele exhibit significantly reduced neutrophil chemotaxis and chemokinesis in vitro and impaired neutrophil recruitment into the peritoneum in a model of thioglycollate-induced aseptic peritonitis. [provided by MGI curators] |
Features --> Cross References
Canonical gene --> CDSs in specific strains.
Canonical gene --> Exons in specific strains
Canonical gene --> Strain-specific IDs, biotypes, and locations
Canonical gene --> Transcripts in specific strains.
Features --> Overlapping features
