| Primary Identifier | MGI:1932915 | Organism | mouse, laboratory |
| Chromosome | 11 | NCBI Gene Number | 83431 |
| Mgi Type | protein coding gene |
| description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0) Enables identical protein binding activity and tubulin binding activity. Involved in several processes, including insulin receptor signaling pathway; lysosome localization; and regulation of plasma membrane bounded cell projection organization. Acts upstream of or within several processes, including cytoskeleton organization; generation of neurons; and transport along microtubule. Located in several cellular components, including axon hillock; cytoskeleton; and synaptic vesicle. Part of microtubule associated complex. Is expressed in several structures, including central nervous system; craniocervical region bone; integumental system; metanephros; and sensory organ. Orthologous to human NDEL1 (nudE neurodevelopment protein 1 like 1). PHENOTYPE: Homozygous inactivation of this gene causes peri-implantation lethality. Blastocysts fail to grow in culture and exhibit inner cell mass degeneration. Compound heterozygous mice carrying one null and one hypomorphic allele show mild neuronal migration defects. [provided by MGI curators] |
Features --> Cross References
Canonical gene --> CDSs in specific strains.
Canonical gene --> Exons in specific strains
Canonical gene --> Strain-specific IDs, biotypes, and locations
Canonical gene --> Transcripts in specific strains.
Features --> Overlapping features
