| Primary Identifier | MGI:3045246 | Organism | mouse, laboratory |
| Chromosome | 11 | NCBI Gene Number | 442801 |
| Mgi Type | protein coding gene |
| description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0) Enables guanyl-nucleotide exchange factor activity. Involved in negative regulation of synapse maturation and regulation of postsynapse assembly. Acts upstream of or within retina vasculature morphogenesis in camera-type eye. Located in dendrite. Is active in glutamatergic synapse and postsynapse. Is expressed in several structures, including adipose tissue; alimentary system; genitourinary system; hemolymphoid system gland; and respiratory system. Orthologous to human ARHGEF15 (Rho guanine nucleotide exchange factor 15). PHENOTYPE: Mice homozygous for a knock out allele exhibit increased excitatory synapse formation. Mice homozygous for a knock-out allele exhibit delayed radial growth, sparse vasculature and empty baselment membrane sleeves in the retina. [provided by MGI curators] |
Features --> Cross References
Canonical gene --> CDSs in specific strains.
Canonical gene --> Exons in specific strains
Canonical gene --> Strain-specific IDs, biotypes, and locations
Canonical gene --> Transcripts in specific strains.
Features --> Overlapping features
