Primary Identifier | MGI:1346074 | Organism | mouse, laboratory |
Chromosome | 11 | NCBI Gene Number | 23879 |
Mgi Type | protein coding gene |
description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0) Predicted to enable mRNA 3'-UTR binding activity; protein dimerization activity; and translation regulator activity. Involved in dentate gyrus development and mRNA destabilization. Located in dendrite and ribosome. Is active in cytoplasm; glutamatergic synapse; and postsynapse. Is expressed in central nervous system; female reproductive system; peripheral nervous system; sensory organ; and skin. Orthologous to human FXR2 (FMR1 autosomal homolog 2). PHENOTYPE: Homozygotes for a targeted null mutation exhibit hyperactivity, impaired Morris water task performance, and reductions in prepulse inhibition, contextual conditioned fear, and sensitivity to heat stimulus. [provided by MGI curators] |