| Primary Identifier | MGI:98086 | Organism | mouse, laboratory |
| Chromosome | 11 | NCBI Gene Number | 20020 |
| Mgi Type | protein coding gene |
| description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 9.1.0) Enables core promoter sequence-specific DNA binding activity. Predicted to be involved in positive regulation of RNA splicing and transcription by RNA polymerase II. Located in euchromatin and nucleus. Is expressed in several structures, including alimentary system; genitourinary system; integumental system; nervous system; and sensory organ. Human ortholog(s) of this gene implicated in chronic obstructive pulmonary disease. Orthologous to human POLR2A (RNA polymerase II subunit A). PHENOTYPE: Homozygotes for a reporter allele show prenatal lethality. Homozygotes for a small deletion in the C-terminal domain are viable, fertile and developmentally normal. Homozygotes for a larger deletion show reduced fetal size and partial postnatal lethality; survivors are small but otherwise normal. [provided by MGI curators] |
Features --> Cross References
Canonical gene --> CDSs in specific strains.
Canonical gene --> Exons in specific strains
Canonical gene --> Strain-specific IDs, biotypes, and locations
Canonical gene --> Transcripts in specific strains.
Features --> Overlapping features
