| Primary Identifier | MGI:106613 | Organism | mouse, laboratory |
| Chromosome | 11 | NCBI Gene Number | 13543 |
| Mgi Type | protein coding gene |
| description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0) Enables several functions, including enzyme binding activity; frizzled binding activity; and identical protein binding activity. Involved in several processes, including heart morphogenesis; positive regulation of GTPase activity; and positive regulation of JUN kinase activity. Acts upstream of or within several processes, including Wnt signaling pathway, planar cell polarity pathway; embryonic morphogenesis; and positive regulation of protein tyrosine kinase activity. Located in several cellular components, including apical part of cell; clathrin-coated vesicle; and lateral plasma membrane. Is expressed in several structures, including alimentary system; brain; early conceptus; genitourinary system; and sensory organ. Used to study dextro-looped transposition of the great arteries. Orthologous to human DVL2 (dishevelled segment polarity protein 2). PHENOTYPE: Homozygous mice show incomplete penetrance of perinatal lethality with surviving mice being predominantly female. Defects include cardiovascular outflow and neural tube abnormalities, malformations of vertebrae and ribs, and irregular somite segmentation. [provided by MGI curators] |
Features --> Cross References
Canonical gene --> CDSs in specific strains.
Canonical gene --> Exons in specific strains
Canonical gene --> Strain-specific IDs, biotypes, and locations
Canonical gene --> Transcripts in specific strains.
Features --> Overlapping features
