| Primary Identifier | MGI:895149 | Organism | mouse, laboratory |
| Chromosome | 11 | NCBI Gene Number | 11370 |
| Mgi Type | protein coding gene |
| description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0) Predicted to enable acyl-CoA dehydrogenase activity; identical protein binding activity; and nucleoside phosphate binding activity. Involved in fatty acid beta-oxidation using acyl-CoA dehydrogenase; regulation of lipid metabolic process; and temperature homeostasis. Acts upstream of or within fatty acid catabolic process and response to cold. Located in mitochondrion. Is expressed in several structures, including central nervous system; genitourinary system; gut gland; heart; and liver. Used to study very long chain acyl-CoA dehydrogenase deficiency. Human ortholog(s) of this gene implicated in very long chain acyl-CoA dehydrogenase deficiency. Orthologous to human ACADVL (acyl-CoA dehydrogenase very long chain). PHENOTYPE: Homozygous mutant animals exhibit mild steatosis, lipid accumulation in myocytes, increased fatigue, impaired temperature regulation, increased susceptibility to arrhythmia, accumulation of long-chain acylcarnitines, and lower free carnitine levels. [provided by MGI curators] |
Features --> Cross References
Canonical gene --> CDSs in specific strains.
Canonical gene --> Exons in specific strains
Canonical gene --> Strain-specific IDs, biotypes, and locations
Canonical gene --> Transcripts in specific strains.
Features --> Overlapping features
