Primary Identifier | MGI:2385729 | Organism | mouse, laboratory |
Chromosome | 11 | NCBI Gene Number | 216864 |
Mgi Type | protein coding gene |
description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0) Enables carbohydrate binding activity. Predicted to be involved in immune response. Predicted to be active in external side of plasma membrane. Is expressed in several structures, including hemolymphoid system gland; ileum; liver; lung; and male reproductive gland or organ. Orthologous to human CLEC10A (C-type lectin domain containing 10A). PHENOTYPE: Mice that are either homozygous or heterozygous for a reporter allele are viable and fertile. In heterozygotes, transient depletion of CD301b+ dermal dendritic cells by injection of diptheria toxin results in impaired T helper 2 (Th2) cell mediated immunity. [provided by MGI curators] |