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Protein Coding Gene : Slc25a11 solute carrier family 25 (mitochondrial carrier oxoglutarate carrier), member 11
Primary Identifier  MGI:1915113 Organism  mouse, laboratory
Chromosome  11 NCBI Gene Number  67863
Mgi Type  protein coding gene
description  FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0)

Enables oxoglutarate:malate antiporter activity. Involved in gluconeogenesis and malate-aspartate shuttle. Located in mitochondrion. Is active in mitochondrial inner membrane. Is expressed in embryo. Human ortholog(s) of this gene implicated in paraganglioma. Orthologous to human SLC25A11 (solute carrier family 25 member 11).
PHENOTYPE: Homozygous knockout is embryonic lethal. Heterozygous KO reduces the tumor incidence of Kras activation mutation-induced lung tumors. [provided by MGI curators]
  • synonyms:
  • solute carrier family 25 (mitochondrial carrier oxoglutarate carrier), member 11,
  • Slc25a11,
  • 2310022P18Rik,
  • RIKEN cDNA 2310022P18 gene,
  • 2oxoc
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Features --> Cross References

Genome

Sequence Feature Displayer

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0 Canonical

0 CDSs

0 Exons

0 Genomic Clusters

2 Involved In Mutations

0 Strain

0 Transcripts

0 Transgenic Expressors

0 UTRs

Canonical gene --> CDSs in specific strains.

Canonical gene --> Exons in specific strains

Canonical gene --> Strain-specific IDs, biotypes, and locations

Canonical gene --> Transcripts in specific strains.

Features --> Overlapping features

Proteins

Gene --> Proteins

Function

Mouse features --> Functions (GO terms)

Homology

Genes --> Homologs

Interactions

8 Pathways

0 Targeted By

Gene --> Protein-Protein Interactions

Expression

Gene --> Expression annotations

Phenotype

Genes/Features --> Phenotypes (MP terms)

Disease

Mouse features --> Human diseases

Literature

Mouse features --> Publications

 

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