| Primary Identifier | MGI:2144284 | Organism | mouse, laboratory |
| Chromosome | 11 | NCBI Gene Number | 103844 |
| Mgi Type | protein coding gene |
| description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0) Enables cyclin binding activity. Acts upstream of or within negative regulation of cyclin-dependent protein serine/threonine kinase activity; negative regulation of fibroblast proliferation; and positive regulation of apoptotic signaling pathway. Predicted to be located in nuclear body. Predicted to be active in cytoplasm. Is expressed in female reproductive system; germ cell of ovary; mesenchymal stroma of ovary; and ovary. Orthologous to human INCA1 (inhibitor of CDK, cyclin A1 interacting protein 1). PHENOTYPE: Mice homozygous for a knock-out allele exhibit decreased cell proliferation in mouse embryonic fibroblasts and older mice exhibit abnormal spleen architecture, particularly in the white pulp, and extramedullary hematopoiesis. [provided by MGI curators] |
Features --> Cross References
Canonical gene --> CDSs in specific strains.
Canonical gene --> Exons in specific strains
Canonical gene --> Strain-specific IDs, biotypes, and locations
Canonical gene --> Transcripts in specific strains.
Features --> Overlapping features
