Primary Identifier | MGI:1914529 | Organism | mouse, laboratory |
Chromosome | 11 | NCBI Gene Number | 67279 |
Mgi Type | protein coding gene |
description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0) Predicted to enable transcription coregulator activity. Predicted to contribute to ubiquitin protein ligase activity. Acts upstream of or within limb development and negative regulation of fibroblast proliferation. Predicted to be located in nucleus. Predicted to be part of core mediator complex; mediator complex; and ubiquitin ligase complex. Is expressed in testis and tibialis anterior. Orthologous to human MED31 (mediator complex subunit 31). PHENOTYPE: Mice homozygous for an ENU-induced allele exhibit developmental delay, reduced cell proliferation, reduced ossification and chondrogenesis, and death during late-gestation. [provided by MGI curators] |