Primary Identifier | MGI:3772572 | Organism | mouse, laboratory |
Chromosome | 11 | NCBI Gene Number | 327959 |
Mgi Type | protein coding gene |
description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0) Predicted to enable molecular sequestering activity. Predicted to be involved in negative regulation of protein-containing complex assembly; negative regulation of type I interferon production; and response to interferon-beta. Predicted to be located in nucleoplasm. Predicted to be active in mitochondrion. Is expressed in embryo. Orthologous to human XAF1 (XIAP associated factor 1). PHENOTYPE: Mice homozygous for a null mutation display resistance to diet induced obesity, improved glucose tolerance and insulin sensitivity, and decreased heat generation. [provided by MGI curators] |