| Primary Identifier | MGI:2384936 | Organism | mouse, laboratory |
| Chromosome | 11 | NCBI Gene Number | 216892 |
| Mgi Type | protein coding gene |
| description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0) Enables sphingolipid transporter activity. Involved in several processes, including regulation of T cell migration; sensory perception of sound; and sphingosine-1-phosphate receptor signaling pathway. Acts upstream of or within several processes, including lymph node development; lymphocyte homeostasis; and regulation of eye pigmentation. Predicted to be located in endosome membrane and plasma membrane. Predicted to be active in membrane. Is expressed in jaw bone; nervous system; sensory organ; and spleen. Human ortholog(s) of this gene implicated in autosomal recessive nonsyndromic deafness 115. Orthologous to human SPNS2 (SPNS lysolipid transporter 2, sphingosine-1-phosphate). PHENOTYPE: Mice homozygous for a knock-out allele exhibit symblepharon and impaired egress of T and B cells from the thymus and bone marrow, respectively. Mice homozygous for a different knock-out allele exhibit abnormal immune system, abnormal eye morphology and absent pinna reflex. [provided by MGI curators] |
Features --> Cross References
Canonical gene --> CDSs in specific strains.
Canonical gene --> Exons in specific strains
Canonical gene --> Strain-specific IDs, biotypes, and locations
Canonical gene --> Transcripts in specific strains.
Features --> Overlapping features
