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Protein Coding Gene : P2rx1 purinergic receptor P2X, ligand-gated ion channel, 1
Primary Identifier  MGI:1098235 Organism  mouse, laboratory
Chromosome  11 NCBI Gene Number  18436
Mgi Type  protein coding gene
description  FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0)

Enables monoatomic cation channel activity and purinergic nucleotide receptor activity. Acts upstream of or within several processes, including positive regulation of cysteine-type endopeptidase activity; regulation of monoatomic ion transport; and serotonin secretion by platelet. Located in external side of plasma membrane and postsynaptic membrane. Is expressed in several structures, including bladder; foregut-midgut junction; heart; liver lobe; and midgut. Orthologous to human P2RX1 (purinergic receptor P2X 1).
PHENOTYPE: Homozygotes for a targeted null mutation exhibit low male fertility due to impaired vas deferens contraction and reduced numbers of ejaculated sperm. Mutants also show mild hypertension and reduced susceptibility to experimental thromboembolism. [provided by MGI curators]
  • synonyms:
  • P2X1 receptor,
  • expressed sequence BB122383,
  • Pdcd3,
  • MGI:105106,
  • BB122383,
  • P2rx1,
  • P2x,
  • programmed cell death 3,
  • AI323649,
  • MGD-MRK-32146,
  • MGI:2144121,
  • expressed sequence AI323649,
  • MGI:2144602,
  • purinergic receptor P2X, ligand-gated ion channel, 1,
  • RP-2
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2 Involved In Mutations

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