Primary Identifier | MGI:2181407 | Organism | mouse, laboratory |
Chromosome | 11 | NCBI Gene Number | 246788 |
Mgi Type | protein coding gene |
description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0) Enables monoatomic cation channel activity. Acts upstream of or within response to temperature stimulus. Located in membrane. Is expressed in central nervous system and sensory organ. Used to study atopic dermatitis. Human ortholog(s) of this gene implicated in colorectal cancer; congenital stationary night blindness; keratosis (multiple); migraine with aura; and schizophrenia. Orthologous to human TRPV3 (transient receptor potential cation channel subfamily V member 3). PHENOTYPE: Homozygous null mice have strong deficits in response to innocuous and noxious heat but not in other sensory modalities. [provided by MGI curators] |