Primary Identifier | MGI:2144305 | Organism | mouse, laboratory |
Chromosome | 11 | NCBI Gene Number | 237859 |
Mgi Type | protein coding gene |
description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0) Predicted to enable mRNA binding activity. Acts upstream of or within in utero embryonic development. Predicted to be located in nuclear speck. Predicted to be part of ribonucleoprotein complex. Is expressed in several structures, including compacted morula; immune system; and oocyte. Orthologous to human NSRP1 (nuclear speckle splicing regulatory protein 1). PHENOTYPE: Mice homozygous for a gene trap allele die prior to E6.5. Homozygous KO in lymphocytes affects alternative splicing of pre-mRNA splicing factors and other genes, which leads to reduced numbers of mature T cells. [provided by MGI curators] |