Primary Identifier | MGI:2667185 | Organism | mouse, laboratory |
Chromosome | 11 | NCBI Gene Number | 360013 |
Mgi Type | protein coding gene |
description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0) Predicted to enable ADP binding activity; ATP binding activity; and actin filament binding activity. Involved in positive regulation of opsonization and regulation of macrophage activation. Acts upstream of or within cellular response to type II interferon. Located in brush border; cytoskeleton; and phagocytic vesicle. Is expressed in several structures, including gonad; lower leg rest of mesenchyme; molar; musculature; and nervous system. Orthologous to human MYO18A (myosin XVIIIA). PHENOTYPE: Homozygotes for a null allele exhibit embryonic lethality before E13.5, with abnormal myofibrils in cardiac myocytes. [provided by MGI curators] |