| Primary Identifier | MGI:1098733 | Organism | mouse, laboratory |
| Chromosome | 11 | NCBI Gene Number | 52466 |
| Mgi Type | protein coding gene |
| description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0) Enables folic acid:proton symporter activity; heme transmembrane transporter activity; and methotrexate transmembrane transporter activity. Involved in folate import across plasma membrane and heme transport. Located in apical plasma membrane and cytoplasm. Is active in basolateral plasma membrane. Is expressed in adrenal gland; early conceptus; gonad; metanephros; and spinal cord. Human ortholog(s) of this gene implicated in hereditary folate malabsorption. Orthologous to human SLC46A1 (solute carrier family 46 member 1). PHENOTYPE: Mice homozygous for a knock-out allele exhibit increased circulating and liver levels of N-homocysteine and total homocysteine. [provided by MGI curators] |
Features --> Cross References
Canonical gene --> CDSs in specific strains.
Canonical gene --> Exons in specific strains
Canonical gene --> Strain-specific IDs, biotypes, and locations
Canonical gene --> Transcripts in specific strains.
Features --> Overlapping features
