| Primary Identifier | MGI:1860086 | Organism | mouse, laboratory |
| Chromosome | 11 | NCBI Gene Number | 54394 |
| Mgi Type | protein coding gene |
| description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0) Predicted to enable DNA binding activity and identical protein binding activity. Predicted to be involved in several processes, including negative regulation of G1/S transition of mitotic cell cycle; positive regulation of receptor signaling pathway via JAK-STAT; and positive regulation of transcription by RNA polymerase II. Predicted to be located in cytosol and plasma membrane. Predicted to be active in nucleus. Is expressed in several structures, including genitourinary system; liver; retina; and thymus primordium. Orthologous to human CRLF3 (cytokine receptor like factor 3). PHENOTYPE: Mice homozygous for a knock-out allele exhibit decreased lean body mass, decreased platelet cell number and increased circulating fructosamine level. Heterozygosity for the p.L389P mutation leads to hippocampal neurons with shorter dendrites with fewer branches. [provided by MGI curators] |
Features --> Cross References
Canonical gene --> CDSs in specific strains.
Canonical gene --> Exons in specific strains
Canonical gene --> Strain-specific IDs, biotypes, and locations
Canonical gene --> Transcripts in specific strains.
Features --> Overlapping features
