| Primary Identifier | MGI:103576 | Organism | mouse, laboratory |
| Chromosome | 11 | NCBI Gene Number | 20292 |
| Mgi Type | protein coding gene |
| description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0) Predicted to enable CCR3 chemokine receptor binding activity; chemokine activity; and protein dimerization activity. Involved in learning or memory; negative regulation of neurogenesis; and positive regulation of angiogenesis. Acts upstream of or within branching involved in mammary gland duct morphogenesis and mammary duct terminal end bud growth. Predicted to be located in extracellular region. Predicted to be active in extracellular space. Is expressed in several structures, including endocardial lining; liver; skin; and yolk sac blood vessel. Human ortholog(s) of this gene implicated in asthma; human immunodeficiency virus infectious disease; and hyperglycemia. Orthologous to human CCL11 (C-C motif chemokine ligand 11). PHENOTYPE: Mice homozygous for a disruption in this gene display decreased numbers of eosinophils and impaired eosinophil recruitment after antigen challenge. However, a different homozygous disruption does not result in eosinophil abnormalities. [provided by MGI curators] |
Features --> Cross References
Canonical gene --> CDSs in specific strains.
Canonical gene --> Exons in specific strains
Canonical gene --> Strain-specific IDs, biotypes, and locations
Canonical gene --> Transcripts in specific strains.
Features --> Overlapping features
