Primary Identifier | MGI:1329013 | Organism | mouse, laboratory |
Chromosome | 11 | NCBI Gene Number | 12467 |
Mgi Type | protein coding gene |
description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0) Predicted to enable protein folding chaperone and unfolded protein binding activity. Predicted to be involved in protein folding. Part of chaperonin-containing T-complex. Is expressed in several structures, including gonad; heart; hemolymphoid system gland; liver; and lung. Orthologous to human CCT6B (chaperonin containing TCP1 subunit 6B). PHENOTYPE: Mice homozygous for null mutations in this gene are viable and show normal male fertility. Interestingly, males homozygous for one null allele remain fertile but show decreased sperm progressive motility and teratospermia characterized by sperm neck bending and cytoplasmic redundancy. [provided by MGI curators] |