Primary Identifier | MGI:1914233 | Organism | mouse, laboratory |
Chromosome | 11 | NCBI Gene Number | 66983 |
Mgi Type | protein coding gene |
description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0) Predicted to enable nucleic acid binding activity and zinc ion binding activity. Involved in several processes, including mitotic DNA replication checkpoint signaling; negative regulation of apoptotic process; and preantral ovarian follicle growth. Acts upstream of or within several processes, including blastocyst growth; intestinal epithelial structure maintenance; and mitotic DNA damage checkpoint signaling. Located in nuclear speck. Is expressed in several structures, including central nervous system; early conceptus; genitourinary system; gut gland; and respiratory system. Orthologous to human ZNF830 (zinc finger protein 830). PHENOTYPE: Homozygous null mice display embryonic lethality with failure of implantation, failure to hatch from the zona pellucida, impaired outgrowth of the inner cell mass and trophectoderm, and prolonged mitosis. [provided by MGI curators] |