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Protein Coding Gene : Unc45b unc-45 myosin chaperone B
Primary Identifier  MGI:2443377 Organism  mouse, laboratory
Chromosome  11 NCBI Gene Number  217012
Mgi Type  protein coding gene
description  FUNCTION: Automated description from the Alliance of Genome Resources (Release 9.1.0)

Enables Hsp90 protein binding activity. Acts upstream of or within protein folding. Located in cytosol. Is expressed in several structures, including gonad; heart; hemolymphoid system gland; liver; and soleus. Human ortholog(s) of this gene implicated in cataract 43 and myofibrillar myopathy 11. Orthologous to human UNC45B (unc-45 myosin chaperone B).
PHENOTYPE: Mice homozygous for a transgenic gene disruption exhibit embryonic lethality at E9 without placental abnormalities. [provided by MGI curators]
  • synonyms:
  • RIKEN cDNA D230041A13 gene,
  • Cmya4,
  • expression sequence AA445617,
  • UNC45,
  • cardiomyopathy associated 4,
  • D230041A13Rik,
  • unc-45 myosin chaperone B,
  • MGI:2671016,
  • Unc45b,
  • AA445617
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Features --> Cross References

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2 Involved In Mutations

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