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Protein Coding Gene : Unc45b unc-45 myosin chaperone B
Primary Identifier  MGI:2443377 Organism  mouse, laboratory
Chromosome  11 NCBI Gene Number  217012
Mgi Type  protein coding gene
description  FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0)

Enables Hsp90 protein binding activity. Acts upstream of or within chaperone-mediated protein folding. Located in cytosol. Is expressed in several structures, including gonad; hemolymphoid system gland; liver; lung; and soleus. Human ortholog(s) of this gene implicated in cataract 43 and myofibrillar myopathy 11. Orthologous to human UNC45B (unc-45 myosin chaperone B).
PHENOTYPE: Mice homozygous for a transgenic gene disruption exhibit embryonic lethality at E9 without placental abnormalities. [provided by MGI curators]
  • synonyms:
  • expression sequence AA445617,
  • UNC45,
  • AA445617,
  • D230041A13Rik,
  • unc-45 myosin chaperone B,
  • Cmya4,
  • Unc45b,
  • cardiomyopathy associated 4,
  • MGI:2671016,
  • RIKEN cDNA D230041A13 gene
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