Primary Identifier | MGI:1927168 | Organism | mouse, laboratory |
Chromosome | 11 | NCBI Gene Number | 56405 |
Mgi Type | protein coding gene |
description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0) Predicted to enable phosphoprotein phosphatase activity. Predicted to be involved in chromatin remodeling and regulation of transcription by RNA polymerase II. Predicted to be located in cytoplasm and nucleus. Is expressed in several structures, including alimentary system; genitourinary system; nervous system; respiratory system; and sensory organ. Orthologous to human DUSP14 (dual specificity phosphatase 14). PHENOTYPE: Homozygous KO results in increased T cell activation, proliferation and differentiation. It also causes increased cardiac hypertrophy in response to aortic banding. [provided by MGI curators] |