| Primary Identifier | MGI:1858214 | Organism | mouse, laboratory |
| Chromosome | 11 | NCBI Gene Number | 53892 |
| Mgi Type | protein coding gene |
| description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0) Predicted to enable mitogen-activated protein kinase binding activity and protein serine/threonine phosphatase activity. Involved in DNA methylation-dependent constitutive heterochromatin formation. Acts upstream of or within DNA damage response, signal transduction by p53 class mediator; G2/M transition of mitotic cell cycle; and response to bacterium. Predicted to be located in cytosol; nucleolus; and nucleoplasm. Is expressed in several structures, including adrenal gland; genitourinary system; gut; hemolymphoid system gland; and integumental system. Human ortholog(s) of this gene implicated in breast cancer. Orthologous to human PPM1D (protein phosphatase, Mg2+/Mn2+ dependent 1D). PHENOTYPE: Homozygous null male mice show some embryonic lethality. Surviving males have variable abnormalities including runting, reproductive organ atrophy with associated reduced fertility, and reduced life span. Both genders have increased susceptibility to viral infection and reduced lymphocyte function. [provided by MGI curators] |
Features --> Cross References
Canonical gene --> CDSs in specific strains.
Canonical gene --> Exons in specific strains
Canonical gene --> Strain-specific IDs, biotypes, and locations
Canonical gene --> Transcripts in specific strains.
Features --> Overlapping features
