| Primary Identifier | MGI:1270849 | Organism | mouse, laboratory |
| Chromosome | 11 | NCBI Gene Number | 72508 |
| Mgi Type | protein coding gene |
| description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0) Enables protein serine/threonine/tyrosine kinase activity. Involved in several processes, including cellular response to type II interferon; long-chain fatty acid import into cell; and negative regulation of TORC2 signaling. Acts upstream of or within several processes, including behavioral fear response; cellular response to dexamethasone stimulus; and negative regulation of signal transduction. Located in mitochondrion. Is active in glutamatergic synapse. Is expressed in several structures, including central nervous system; early conceptus; leg muscle; reproductive system; and retina nuclear layer. Orthologous to human RPS6KB1 (ribosomal protein S6 kinase B1). PHENOTYPE: Homozygotes for a targeted null mutation exhibit reduced prenatal growth, glucose intolerance, and hypoinsulinemia associated with diminished pancreatic beta cell size. [provided by MGI curators] |
Features --> Cross References
Canonical gene --> CDSs in specific strains.
Canonical gene --> Exons in specific strains
Canonical gene --> Strain-specific IDs, biotypes, and locations
Canonical gene --> Transcripts in specific strains.
Features --> Overlapping features
