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Protein Coding Gene : Vmp1 vacuole membrane protein 1
Primary Identifier  MGI:1923159 Organism  mouse, laboratory
Chromosome  11 NCBI Gene Number  75909
Mgi Type  protein coding gene
description  FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0)

Predicted to enable phospholipid scramblase activity. Involved in autophagy and lipoprotein transport. Acts upstream of or within embryo implantation. Located in phagophore assembly site. Orthologous to human VMP1 (vacuole membrane protein 1).
PHENOTYPE: Mice homozygous for a null allele exhibit embryonic lethality between E7.5 and E9.5 with reduced size at E7.5 and neutral lipid accumulation in visceral endoderm cells. Mice homozygous for a conditional allele activated in intestinal epithelia exhibit reduced body weight and neutral lipid accumulation in intestinal epithelia. [provided by MGI curators]
  • synonyms:
  • 4930579A11Rik,
  • Vmp1,
  • RIKEN cDNA 3110098I04 gene,
  • expressed sequence AI787464,
  • MGI:1925760,
  • transmembrane protein 49,
  • RIKEN cDNA 4930579A11 gene,
  • Tango5,
  • AI787464,
  • 3110098I04Rik,
  • vacuole membrane protein 1,
  • MGI:2144264,
  • Tmem49
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