Primary Identifier | MGI:2676885 | Organism | mouse, laboratory |
Chromosome | 11 | NCBI Gene Number | 387140 |
Mgi Type | miRNA gene |
description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0) Enables mRNA 3'-UTR binding activity. Involved in miRNA-mediated post-transcriptional gene silencing. Acts upstream of or within several processes, including cellular response to cytokine stimulus; cellular response to dexamethasone stimulus; and regulation of gene expression. Part of RISC complex. Is expressed in lung. PHENOTYPE: Mice homozygous for a knock-out allele exhibit normal cardiac morphology and response to stress, with the exception of a mildly exaggerated increase in heart weight in Ang II-treated mice. [provided by MGI curators] |