| Primary Identifier | MGI:107375 | Organism | mouse, laboratory |
| Chromosome | 11 | NCBI Gene Number | 18559 |
| Mgi Type | protein coding gene |
| description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0) Predicted to enable phosphatidylcholine binding activity and phosphatidylcholine transporter activity. Involved in negative regulation of cold-induced thermogenesis. Acts upstream of or within cholesterol metabolic process. Located in cytosol. Is expressed in several structures, including genitourinary system; hemolymphoid system gland; intestine; liver; and stomach. Orthologous to human PCTP (phosphatidylcholine transfer protein). PHENOTYPE: Mice homozygous for a knock-out allele display impaired biliary lipid secretion in response to a lithogenic diet, and show altered adaptive responses of macrophages to cholesterol loading. Mice heterozygous for a spontaneous allele show lack of phosphatidylcholine transfer protein activity. [provided by MGI curators] |
Features --> Cross References
Canonical gene --> CDSs in specific strains.
Canonical gene --> Exons in specific strains
Canonical gene --> Strain-specific IDs, biotypes, and locations
Canonical gene --> Transcripts in specific strains.
Features --> Overlapping features
