Primary Identifier | MGI:1923658 | Organism | mouse, laboratory |
Chromosome | 11 | NCBI Gene Number | 76408 |
Mgi Type | protein coding gene |
description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0) Predicted to enable ABC-type transporter activity; glucuronoside transmembrane transporter activity; and icosanoid transmembrane transporter activity. Predicted to be involved in carboxylic acid transport; monoatomic anion transmembrane transport; and xenobiotic transmembrane transport. Predicted to act upstream of or within canalicular bile acid transport. Located in basolateral plasma membrane. Is expressed in alimentary system; embryo; liver; and small intestine. Orthologous to human ABCC3 (ATP binding cassette subfamily C member 3). PHENOTYPE: Mice homozygous for disruptions in this gene exhibit increased liver bile acid levels after bile duct ligation [provided by MGI curators] |