| Primary Identifier | MGI:2387581 | Organism | mouse, laboratory |
| Chromosome | 11 | NCBI Gene Number | 217124 |
| Mgi Type | protein coding gene |
| description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0) Predicted to enable several functions, including D2 dopamine receptor binding activity; enzyme binding activity; and transmembrane transporter binding activity. Involved in cellular response to morphine; regulation of opioid receptor signaling pathway; and regulation of postsynapse assembly. Acts upstream of or within several processes, including actin filament organization; calcium-mediated signaling; and dendrite development. Located in cortical actin cytoskeleton and filopodium. Is expressed in several structures, including alimentary system; brain; connective tissue; genitourinary system; and hemolymphoid system. Orthologous to human PPP1R9B (protein phosphatase 1 regulatory subunit 9B). PHENOTYPE: Homozygotes for a targeted null mutation exhibit abnormal glutamatergic synaptic transmission, reduced long-term depression, resistance to kainate-induced seizures, impaired taste aversion learning, and increased dendritic spine density. [provided by MGI curators] |
Features --> Cross References
Canonical gene --> CDSs in specific strains.
Canonical gene --> Exons in specific strains
Canonical gene --> Strain-specific IDs, biotypes, and locations
Canonical gene --> Transcripts in specific strains.
Features --> Overlapping features
