| Primary Identifier | MGI:96189 | Organism | mouse, laboratory |
| Chromosome | 11 | NCBI Gene Number | 15416 |
| Mgi Type | protein coding gene |
| description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0) Enables DNA-binding transcription repressor activity, RNA polymerase II-specific and sequence-specific DNA binding activity. Involved in negative regulation of myeloid cell differentiation and negative regulation of transcription by RNA polymerase II. Acts upstream of or within several processes, including dorsal spinal cord development; embryonic skeletal system morphogenesis; and grooming behavior. Predicted to be located in nucleoplasm. Predicted to be active in nucleus. Is expressed in several structures, including embryo mesenchyme; extraembryonic component; genitourinary system; nervous system; and neural ectoderm. Used to study trichotillomania. Orthologous to human HOXB8 (homeobox B8). PHENOTYPE: Most homozygotes for targeted null mutations exhibit delayed preweaning growth, degeneration of the second spinal ganglion, axial skeletal defects, impaired clasping, an altered gait, and excessive grooming. [provided by MGI curators] |
Features --> Cross References
Canonical gene --> CDSs in specific strains.
Canonical gene --> Exons in specific strains
Canonical gene --> Strain-specific IDs, biotypes, and locations
Canonical gene --> Transcripts in specific strains.
Features --> Overlapping features
