Primary Identifier | MGI:96187 | Organism | mouse, laboratory |
Chromosome | 11 | NCBI Gene Number | 15414 |
Mgi Type | protein coding gene |
description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0) Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Acts upstream of or within anterior/posterior pattern specification; embryonic skeletal system morphogenesis; and erythrocyte homeostasis. Predicted to be active in nucleus. Is expressed in several structures, including alimentary system; central nervous system; early conceptus; embryo mesenchyme; and genitourinary system. Orthologous to human HOXB6 (homeobox B6). PHENOTYPE: Homozygotes for a targeted null mutation exhibit an anteriorizing homeotic transformation of the cervicothoracic vertebrae C6-T1, and frequently a missing first rib and a bifid second rib. [provided by MGI curators] |