| Primary Identifier | MGI:99421 | Organism | mouse, laboratory |
| Chromosome | 11 | NCBI Gene Number | 18023 |
| Mgi Type | protein coding gene |
| description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0) Enables several functions, including DNA-binding transcription factor activity, RNA polymerase II-specific; cholesterol binding activity; and promoter-specific chromatin binding activity. Involved in several processes, including cell redox homeostasis; cellular response to cholesterol; and cholesterol homeostasis. Acts upstream of or within several processes, including neurogenesis; regulation of organelle organization; and regulation of primary metabolic process. Located in endoplasmic reticulum membrane and nucleus. Part of protein-containing complex. Is expressed in several structures, including central nervous system; early conceptus; female reproductive system; head mesenchyme; and urinary system. Used to study hepatocellular carcinoma and type 2 diabetes mellitus. Orthologous to human NFE2L1 (NFE2 like bZIP transcription factor 1). PHENOTYPE: Homozygotes for targeted null mutations fail to form a primitive streak, lack mesoderm, show a non-cell autonomous defect in definitive erythropoiesis, and die around embryonic day 7.5. [provided by MGI curators] |
Features --> Cross References
Canonical gene --> CDSs in specific strains.
Canonical gene --> Exons in specific strains
Canonical gene --> Strain-specific IDs, biotypes, and locations
Canonical gene --> Transcripts in specific strains.
Features --> Overlapping features
