Primary Identifier | MGI:1926162 | Organism | mouse, laboratory |
Chromosome | 11 | NCBI Gene Number | 78912 |
Mgi Type | protein coding gene |
description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0) Predicted to enable DNA-binding transcription repressor activity, RNA polymerase II-specific; RNA polymerase II cis-regulatory region sequence-specific DNA binding activity; and histone deacetylase binding activity. Acts upstream of or within several processes, including embryonic organ development; fibroblast proliferation; and in utero embryonic development. Predicted to be located in nucleoplasm. Is expressed in several structures, including branchial arch; early conceptus; neural ectoderm; testis; and urinary system. Orthologous to human SP2 (Sp2 transcription factor). PHENOTYPE: No homozygous null mice survived beyond E10.5, with decrease embryo size and embryonic growth retardation starting at E7.5. [provided by MGI curators] |