| Primary Identifier | MGI:1932575 | Organism | mouse, laboratory |
| Chromosome | 11 | NCBI Gene Number | 83395 |
| Mgi Type | protein coding gene |
| description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0) Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Involved in epithelial to mesenchymal transition and odontogenesis. Acts upstream of or within regulation of odontogenesis. Predicted to be located in cytosol and nucleus. Is expressed in several structures, including branchial arch; genitourinary system; limb ectoderm; limb epithelium; and tooth. Human ortholog(s) of this gene implicated in amelogenesis imperfecta type 1K. Orthologous to human SP6 (Sp6 transcription factor). PHENOTYPE: Mice homozygous for a disruption at this locus display impaired skin, hair follicle, tooth and lung development as well as limb abnormalities and partial postnatal lethality. [provided by MGI curators] |
Features --> Cross References
Canonical gene --> CDSs in specific strains.
Canonical gene --> Exons in specific strains
Canonical gene --> Strain-specific IDs, biotypes, and locations
Canonical gene --> Transcripts in specific strains.
Features --> Overlapping features
