| Primary Identifier | MGI:2651588 | Organism | mouse, laboratory |
| Chromosome | 11 | NCBI Gene Number | 192157 |
| Mgi Type | protein coding gene |
| description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0) Enables phosphorylation-dependent protein binding activity and ubiquitin-like ligase-substrate adaptor activity. Involved in proteasome-mediated ubiquitin-dependent protein catabolic process. Acts upstream of or within several processes, including brain development; fat cell differentiation; and insulin receptor signaling pathway. Part of Cul5-RING ubiquitin ligase complex. Is expressed in several structures, including brain; eye; liver; lung; and testis. Orthologous to human SOCS7 (suppressor of cytokine signaling 7). PHENOTYPE: Homozygous null mice display partial penetrance of hydroencephaly, premature death, intracranial hemorrhage, abnormally large islets of Langerhans and fully penetrant disorganization of the subcommissural organ and reduced body weight. [provided by MGI curators] |
Features --> Cross References
Canonical gene --> CDSs in specific strains.
Canonical gene --> Exons in specific strains
Canonical gene --> Strain-specific IDs, biotypes, and locations
Canonical gene --> Transcripts in specific strains.
Features --> Overlapping features
