| Primary Identifier | MGI:94860 | Organism | mouse, laboratory |
| Chromosome | 11 | NCBI Gene Number | 19049 |
| Mgi Type | protein coding gene |
| description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0) Predicted to enable dopamine receptor binding activity and protein phosphatase inhibitor activity. Acts upstream of or within several processes, including negative regulation of female receptivity; response to cocaine; and visual learning. Located in cytoplasm; neuronal cell body; and nucleus. Is expressed in central nervous system; limb mesenchyme; nucleus pulposus; retina; and ureteric tip. Human ortholog(s) of this gene implicated in bipolar disorder and schizophrenia. Orthologous to human PPP1R1B (protein phosphatase 1 regulatory inhibitor subunit 1B). PHENOTYPE: Homozygotes for a targeted null mutation exhibit elevated substance P-like immunoreactivity and deficits in responses to dopamine, cocaine, ethanol, and antipsychotic drugs. Abnormalities in striatal function were also noted. [provided by MGI curators] |
Features --> Cross References
Canonical gene --> CDSs in specific strains.
Canonical gene --> Exons in specific strains
Canonical gene --> Strain-specific IDs, biotypes, and locations
Canonical gene --> Transcripts in specific strains.
Features --> Overlapping features
