| Primary Identifier | MGI:1913862 | Organism | mouse, laboratory |
| Chromosome | 11 | NCBI Gene Number | 66612 |
| Mgi Type | protein coding gene |
| description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0) Acts upstream of or within several processes, including negative regulation of B cell apoptotic process; negative regulation of ceramide biosynthetic process; and negative regulation of serine C-palmitoyltransferase activity. Predicted to be located in endoplasmic reticulum. Predicted to be part of serine palmitoyltransferase complex. Is expressed in lung. Orthologous to human ORMDL3 (ORMDL sphingolipid biosynthesis regulator 3). PHENOTYPE: Mice homozygous for a knock-out allele exhibit a small spleen with a lower ratio of white pulp to red pulp and disproportional B cell subsets. [provided by MGI curators] |
Features --> Cross References
Canonical gene --> CDSs in specific strains.
Canonical gene --> Exons in specific strains
Canonical gene --> Strain-specific IDs, biotypes, and locations
Canonical gene --> Transcripts in specific strains.
Features --> Overlapping features
